Web26 feb 2014 · ILC3 are heterogeneous in the expression of several markers, including CD4 and NKp46 [5– 8, 10– 14, 37]. We found that lung ILC3 do not express CD4, and only low levels of CD25 were detected. Such phenotype might explain the discrepancy between our data and those from the study by Monticelli et al, who used CD25 to sort out total ILCs … WebThPOK is selectively expressed in class II-restricted cells at the CD4 (+)8 (lo) stage and is necessary and sufficient for development to the CD4 lineage.
Runx3 specifies lineage commitment of innate lymphoid cells
WebILC3s are shown in orange. Type 3 innate lymphoid cells ( ILC3) are immune cells from the lymphoid lineage that are part of the innate immune system. These cells participate in innate mechanisms on mucous membranes, contributing to tissue homeostasis, host-commensal mutualism and pathogen clearance. Web26 lug 2024 · The transcription factor ThPOK is critical for homeostasis and differentiation of mature helper T cells. Here, Kappes and colleagues describe a ThPOK-mediated … indiamplify
转录因子ThPok调控NKT细胞在自身免疫性肝炎中的作用探讨
Web24 lug 2016 · Gli antigeni di questi batteri inducono la produzione di IL-1beta da parte dei macrofagi, che stimola la produzione di GM-CSF da parte delle cellule ILC3, questa molecola stimola la produzione di acido retinoico da parte degli stessi macrofagi che attivano così le cellule T regolatrici, necessarie per il mantenimento della tolleranza … Web7 set 2008 · ThPOK is necessary for the differentiation of CD4+ helper T cells. Three new studies indicate that, unexpectedly, ThPOK is required only after initial specification to the CD4+ lineage. WebThe transcription factor ThPOK (encoded by the Zbtb7b gene) controls homeostasis and differentiation of mature helper T cells, while opposing their differentiation to CD4 + intraepithelial lymphocytes (IELs) in the intestinal mucosa. Thus CD4 IEL differentiation requires ThPOK transcriptional repression via reactivation of the ThPOK transcriptional … indiacloussecurity