WebApr 8, 2024 · 2 A multi-omic dissection of super-enhancer driven oncogenic gene 3 4 expression programs in ovarian cancer 5 ... 56 target genes for these super-enhancers and later confirmed their activity specifically within the 57 cancer cell compartment of human tumors using single-cell genomics data. Together, our multi- WebJul 6, 2024 · SEs are typically defined as a subset of enhancers exceeding the inflection point of the curve ( Figure 1 A). Genome-wide SE profiling is performed by mapping the SEs identified in each sample to the union SEs across all …
Super-enhancers: a new frontier for epigenetic modifiers in cancer ...
WebApr 11, 2024 · In this review, we highlighted the underlying mechanism of action of SEs in cancer development and the corresponding novel potential therapeutic strategies. It is … WebSuper-enhancers, characterized as large clusters of enhancers in close proximity, have been identified as essential oncogenic drivers required for the maintenance of cancer cell identity. As a result, cancer cells are often addicted to the … info-ucass-edu-cn
Super enhancer inhibitors suppress MYC driven transcriptional
WebResearch Article The BRD4 Inhibitor dBET57 Exerts Anticancer Effects by Targeting Superenhancer-Related Genes in Neuroblastoma Si-Qi Jia ,1,2 Ran Zhuo ,1,3 Zi-Mu Zhang ,1 Yang Yang ,1 Yan-Fang Tao,1 Jian-Wei Wang,1 Xiao-Lu Li,1 Yi Xie,1 Gen Li,1 Di Wu,1 Yan-Ling Chen,1 Juan-Juan Yu,1 Chen-xi Feng,1 Zhi-Heng Li,1 Rong-Fang Zhou,1 Ran-Dong Yang,1 … WebThe term 'super-enhancer' has been used to describe groups of putative enhancers in close genomic proximity with unusually high levels of Mediator binding, as measured by chromatin immunoprecipitation and sequencing (ChIP-seq). Here we review the identification and composition of super-enhancers, de … WebDec 16, 2024 · Recently, the term 'super-enhancer' has been introduced to describe a hyper-active regulatory domain comprising a complex array of sequence elements that work … info uberlube.com