2024 Read across approach toxicology

Read across approach toxicology

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August undefined, 2024

WebJun 23, 2024 · The concept of chemical similarity has many applications in several fields of cheminformatics. One common use of chemical similarity measurements, based on the principle that similar molecules have similar properties, is in the context of the read-across approach, where estimates of a specific endpoint for a chemical are obtained starting … WebJun 10, 2013 · Considerations before embarking on a read-across approach have been discussed at length elsewhere [16,17,19, 20, 27]. The types of considerations vary to a degree depending on the decision context ...

Society of Toxicology (SOT)

WebComputational Toxicology Generalised Read-Across GenRA, research, implementation and practical application. ToxPi. PRIORITIZATION. Interactive Chemica Sl afety for Sustainability Web Application TOXCAST iCSS v0.5 Tool Tip Description of Assays (Data) or . Prioritization Mode whatever is being hovered over Desc Summary Log 80-05-7 80-05-1 80-05 ... WebFeb 6, 2024 · Toxicology and Environmental Research and Consulting, Dow Chemical, Midland, Michigan, USA. Search for more papers by this author. Lennart Weltje, ... In addition, the degree of validation needed to provide sufficient confidence in a given read-across approach has to be decided. Another complicating factor is the difference in validation ... effinger bicycle

Critical Review of Read‐Across Potential in Testing for Endocrine ...

WebDec 1, 2024 · Advancing the science of a read-across framework for evaluation of data-poor chemicals incorporating systematic and new approach methods Regulatory Toxicology and Pharmacology, Volume 137, 2024, Article 105293 Show abstract Research article Nitrocellulose blister material as a source of N-nitrosamine contamination of … Weband read across approach. Case Studies – Examples of NAMs Prediction of a 90 day Repeated Dose Toxicity Study . for 2-Ethylbuturic acid using a . read-across approach to other branched carboxylic acids. ... (NAM) for regulatory toxicology. ALTEX. 2024 Apr 30. doi: 10.14573/altex.1912181. effinger consulting

Read Across Approaches: Chemical Structure and Bioactivity …

Bibra Read-Across

WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has been used in a relatively specialist context implying “accepted” structural similarity, particularly within well-defined chemical classes. WebAug 8, 2024 · Read-across has become the essential technique to fill toxicological data gaps. Whilst the term “read-across” has been used since the 1980s, until recently it has … contents of vegemiteWebComputational Toxicology 3 Definitions: Read-across • Read-across describes the method of filling a data gap whereby a chemical with existing data values is used to make a prediction for a ‘similar’ chemical. • A target chemical is a chemical which has a data gap that needs to be filled i.e. the subject of the read-across. • contents of vedas

"WebRead-Across • According to FDA’s Predictive Toxicology Roadmap read across is a methodology that “uses data from a data-rich substance for a data-poor substance that is … " - Read across approach toxicology

Read across approach toxicology

Read-Across Assessment Framework (RAAF) - Europa

WebSociety of Toxicology (SOT) WebJan 1, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. ... The read-across approach starts with structural ...

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Webread-across hypothesis and the information requirement to be read across The RAAF defines two general read-across hypotheses: 1. (Bio)transformation into a common toxicant • Toxicokinetic information may support the approach 2. Different compounds have the same type of effects • Toxicodynamic information may support the approach WebRead-across is one of the most frequently used alternative tools for hazard assessment, in particular for complex endpoints such as repeated dose or developmental and reproductive toxicity. Read-across extrapolates the outcome of a specific toxicological in vivo endpoint from tested (source) compounds to "similar" (target) compound (s).

WebMar 27, 2024 · We developed Generalized Read-Across (GenRA) ( Shah et al., 2016) for automated read-across prediction of a property of a chemical (called the target) as a similarity weighted average of the same property from analogues (also referred to as source analogues) ( Low et al., 2013 ). WebCategory formation, grouping and read across methods are broadly applicable in toxicological assessments and may be used to fill data gaps for chemical safety …

WebJoin us for a Generalized Read Across (GenRA) Virtual Training May 23, 2024 11:00 a.m. – 1:30 p.m. EDT The US Environmental Protection Agency (EPA)'s Generalized Read-Across (GenRA) tool is a freely-available, automated approach to make reproducible read-across predictions of toxicity outcomes. This training will include: A presentation overview of … WebSep 26, 2024 · A read-across assessment is using the technique of predicting toxicity data for one compound, named as target compound (TC), by using data for the same endpoint …

WebDec 2, 2024 · Integrating computational chemistry and toxicology can improve the read-across analog approach to fill data gaps in chemical safety assessment. In read-across, structure-related parameters are compared between a target chemical with insufficient test data and one or more materials with sufficient data. Recent advances have focused on …

Web1 day ago · Venous thromboembolism (VTE) comprising deep venous thrombosis and pulmonary embolism is a major cause of morbidity and mortality. Short-term immobility-related conditions are a major risk factor for the development of VTE. Paradoxically, long-term immobilized free-ranging hibernating brown bears and paralyzed spinal cord injury … effingee productionsWebToxicology Letters 116(S1), 61. Potts RO, Guy RH. (1992). Predicting skin permeability. ... The UK Environmental Agency have a similar approach to read across as the HSE though appropriate ecotoxicity tests such as acute toxicity to Daphnia form the basis of establishing the validity of their read acrosses.The approach is also a step-by-step ... contents of vapeWebRead-across has generated much attention since it may be used as an alternative approach for addressing the information requirements under regulatory programmes, notably the EU's REACH regulation. effinger brewery barabooWebRead-across (RAx) translates available information from well-characterized chemicals to a substance for which there is a toxicological data gap. The OECD is working on case … contents of vitamin waterWebThe use of toxicity data on a structurally-similar compound to evaluate a substance that has been inadequately tested – the so-called “read-across” approach – is a crucial part of the … contents of vicks vaporubWeb• Computational toxicologist expert in in silico chemical safety assessment • Professional expertise in generating (eco)toxicological and physicochemical data by means of in silico approaches (QSAR, expert systems and read-across) in compliance with the current regulations (e.g., REACH, CLP, ICH M7 guideline, Biocides and Cosmetics … effinger health npiWebJan 1, 2024 · These preliminary biological data-driven read-across studies highlight the road to the new generation of read-across approaches that can be applied in chemical safety … contents of veins