WebJul 1, 1982 · The degree of neuro- toxicity correlated with drug concentration. Purkinje cells were the most susceptible of the cerebellar elements, and intracerebellar nucleus neurons were the most resistant. In contrast, mature mouse cerebellar explants were resistant to chronic exposure to high concentrations of phenytoin. WebJan 1, 1995 · We report a patient with phenytoin neurotoxicity who had not been prescribed the drug. Case report. A 36-year-old man came to the emergency department with nausea and unsteady gait. Examination revealed oscillopsia, dysarthria, and severe ataxia. Phenytoin serum level was 28 micrograms/ml. Over the next 3 days his symptoms …
Clinical experience with new antiepileptic drugs ... - PubMed
WebJun 1, 2011 · Combining drugs that block voltage-dependent sodium channels is more likely to produce neurotoxic side-effects, such as dizziness, diplopia and ataxia. 71, 79, 80, 81 A similar scenario, particularly related to a greater likelihood of dizziness, has been reported in patients established on traditional sodium channel blockers compared with those … WebSep 23, 2015 · Phenytoin g: 30: 30--100: 100: Ethosuximide h--100: 300-- ... However, compounds 10, 11, 12b, 12c, 12f, 12k, 16, 17 and 18b revealed neurotoxicity at a dose of 300 mg/kg after 0.5 h and turned out to be non-toxic after 4 h. All the most active molecules, namely 12c, 12d and 18b, showed anticonvulsant potencies in lower doses than … gacha flower
Phenytoin Toxicity - StatPearls - NCBI Bookshelf
WebMar 30, 2024 · Neurotoxicity can occur as a side effect of chemotherapy, radiation therapy, drug therapies, organ transplantation, and vulnerability to heavy metals such as mercury … WebAbstract. Phenytoin is an 80-year young molecule and new indications are still emerging. The neuroprotective potential of phenytoin has been evaluated for decades. Recently, a … Webphenytoin [ 9 ] . Neurotoxicity may occur in combina-tion with phenytoin, and other voltage-gated sodium channel blocking antiepileptic drugs, consequent to a pharmacodynamic interaction [ 10 ] . Lamotrigine Does not affect the pharmacokinetics of phenytoin [ 11 ] . During combination therapy with ... gacha fits