WebOct 1, 2014 · Members of the Arf family of small GTP-binding (G) proteins are key regulators of eukaryotic cell organization. Arf1 is the founding member of the family, and was originally identified as a protein factor required for the ADP-ribosylation of the adenylate cyclase activator Gsα by cholera toxin (Kahn and Gilman, 1986).There are three classes … WebNov 1, 2002 · Arf proteins are important regulators of cellular traffic and the founding members of an expanding family of homologous proteins and genomic sequences. They depart from other small GTP-binding proteins by a unique structural device, which we call the ‘interswitch toggle’, that implements front–back communication from the N-terminus …
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WebThe ARF protein is part of an ARF/MDM2/p53 signaling pathway that negatively regulates cell growth through the capacity of the p53 transcription factor to induce cell cycle arrest … WebOct 1, 2014 · Members of the Arf family of small GTP-binding (G) proteins are key regulators of eukaryotic cell organization. Arf1 is the founding member of the family, and … holland park gate lodha
ARF family G proteins and their regulators: roles in …
WebADP-ribosylation factor domain protein 1 (ARD1) is a 64-kDa protein that contains an 18-kDa carboxyl-terminal ARF domain and a 46-kDa amino-terminal domain. This distinctive member of the ARF family was originally identified during screening of a HL-60 cell cDNA 1 ZAP library. 14 A single clone hybridized with the ARF2 cDNA and failed to ... WebThe ARF proteins are ubiquitously expressed and the amino-acid sequences seem to be well conserved in all eukaryotes, from yeast to humans, with remarkable fidelity. WebNov 8, 2024 · The Arf family is composed of 30 members: the six “true” Arfs, 21 Arf-like proteins (Arls), 2 Sars, and Trim23 (Li et al., 2004; Kahn et al., 2006).The Arfs are closely related, while the other members are more divergent in sequence and cellular functions (reviewed in Gillingham and Munro, 2007; Donaldson and Jackson, 2011; Sztul et al., … human interest news value