WebJun 12, 2013 · The identification in tumor cells of a cytoprotective function of autophagy in response to chemotherapy or radiation has generated a number of clinical trials designed to evaluate the possibility that interference with autophagy could be a generalized strategy for improving the response to cancer therapeutics. 1 However, it is important to recognize … WebJan 20, 2012 · Autophagy is activated by various stresses, including DNA damage, and previous studies of DNA damage-induced autophagy have focused on the response to chemotherapeutic drugs, ionizing radiation, and reactive oxygen species. In this study, we investigated the biological significance of autophagic response to ultraviolet (UV) …
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WebEndogenously, Nrf2 elicits a graded cytoprotective response proportional to the scale and repetition of cytotoxic insult. Thus, basal Nrf2 expression reflects the current cellular stress climate. Basal Nrf2 expression was comparable between CON and mdx quadriceps consistent with stablised disease in mdx mice of this age (Figure 1(A)). WebNov 2, 2009 · Autophagy is regulated by a group of autophagy-specific gene (ATG) genes that function to sense environmental stress, assemble double- or multimembrane-bound … dr earth bloom
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WebMany cytoprotective enzymes induced in response to oxidative stress are regulated primarily at the transcriptional level ; for this reason we carefully analyzed transcriptomic data looking for other alterations related with pathways involved … A gastric cytoprotectant is any medication that combats ulcers not by reducing gastric acid but by increasing mucosal protection. Examples of gastric cytoprotective agents include prostaglandins which protect the stomach mucosa against injury by increasing gastric mucus secretion. Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit the synthesis of prostaglandins and thereby make the stomach more susceptible to injury. Gastric cytoprotective drugs include carbenoxolone, … WebMay 19, 2024 · Mesenchymal stem cells (MSCs) protect tissues against cell death induced by ischemia/reperfusion insults. This therapeutic effect seems to be controlled by physiological cues released by the local ... dr earth bone meal