WebFunction. Has E3 ubiquitin-protein ligase activity and may target misfolded substrates towards proteasomal degradation. Regulates the activity of some serine/threonine … WebJun 28, 2024 · Abstract. CHIP (C-terminus of Hsc70-interacting protein) and its worm ortholog CHN-1 are E3 ubiquitin ligases that link the chaperone system with the ubiquitin-proteasome system (UPS). CHN-1 can cooperate with UFD-2, another E3 ligase, to accelerate ubiquitin chain formation; however, the basis for the high processivity of this …
E3 Ubiquitin Ligase CHIP and NBR1-Mediated Selective …
WebApr 8, 2024 · The ChIP assay and dual luciferase reporter assay confirmed two potential FOXA2-binding sites on the IRAK1 gene promoter predicted by using the JASPAR database. Findings from the current study identified a novel relationship among STING, FOXA2, and IRAK1, providing new insights into the mechanism of the gain of IRAK1 … WebJul 9, 2024 · A C-terminus of heat shock protein (Hsp) 70-interacting protein [carboxy-terminal Hsp70-interacting protein (CHIP)] is a chaperone-dependent and U-box-containing E3 ligase. CHIP is a key molecule in PQC by recognizing misfolded proteins through its interacting chaperones and targeting their degradation. CHIP also ubiquitinates native … clockify for salesforce
Radiation induces IRAK1 expression to promote radioresistance by ...
WebJan 1, 2011 · The carboxy-terminus of Hsc70 interacting protein (CHIP) is known to function as a chaperone associated E3 ligase for several proteins and regulates a variety of physiological processes. Being a connecting link between molecular chaperones and 26S proteasomes, it is widely regarded as the central player in the cellular protein quality … WebNational Center for Biotechnology Information WebThe carboxy-terminus of Hsc70 interacting protein (CHIP) is a cochaperone E3 ligase containing three tandem repeats of tetratricopeptide (TPR) motifs and a C-terminal U-box … boca to homestead